Two New Scientific Studies Reveal
Citrus Bergamot Extract (38%)
is Strikingly Effective for Epidemic
Fatty Liver Conditions

The formulation in BergaMet L is identical to the formula used in the two separate studies conducted
in Italy that shows a powerful benefit to patients with nonalcoholic fatty liver disease (NAFLD)

Alarming statistics about NAFLD

1: NAFLD is currently the most common liver disease in the US and Worldwide
2: Affects 10-24% of the world’s population
3: Upwards of 29 million Americans with NAFLD
4: Significant number of children in the US with NAFLD
5: 2 recent studies reveal BergaMet is strikingly effective for NAFLD
6: BergaMet converted severe steatosis to moderate category in 12 weeks
7: Standard liver function blood test quickly normalized in the majority of patients
8: Only know product to decrease hepatic fat and improve liver function
9: 50% reduction in liver fat, 40% improvement in steato test.

Latest News: Clinical Study

The effect of BPF (47%) on endothelial dysfunction of patients with hyperlipemia and Non Alcoholic Fatty Liver Disease: a double blind, randomized, placebo-controlled study

Accepted for publication Pharmanutrition in March 2017

A total of 188 patients were enrolled at the San Raffaele IRCCS, Rome. The inclusion criteria were adults with NAFLD and hyperlipemia. A fatty liver was diagnosed by abdominal ultrasonography consistent with conventional criteria. This study was conducted according to the guidelines established in the Declaration of Helsinki, and all procedures involving human participants were approved by the Ethic Committee of the San Raffaele IRCCS, Rome (EudraCT Number 2015-002980-24). A 16-week, randomized, double-blind, placebo-controlled study was conducted between November 2015 and September 2016 to assess 1) the hepatoprotective effect of bergamot polyphenolic Fraction (BPF 47%). The participants were randomized using a random number generator in Excel software (Microsoft, Seattle, WA) to receive BPF 47% (650 mg twice a day ; n = 95) or placebo (n = 93). Each participant was instructed to maintain his habitual mode of living, including diet, physical activity, and alcohol consumption, during the study. Participants returned at 16 weeks to provide a fasting blood sample and undergo liver ultrasound examination.


The beneficial effect of treating with BPF 47% patients with hyperlipemia associated to NAFLD was confirmed by data obtained when studying ultrasonografic pattern of NAFLD. Indeed, hepatorenal index was significantly (P < 0.05) reduced from 3.1 ± 0.4 to 1.8 ± 0.5 by treatment with BPF showing a reduction of liver brightness. This suggests that treating patients suffering from mild to severe NAFLD associated with Metabolic Syndrome with BPF 47% (650 mg twice a day for 16 weeks) leads to reduction of hepatic ultrosonographic pattern of NAFLD.

How it works

The antioxidants and unique polyphenols compounds in Beramot help promote liver and cardiovasular health by restoring the antioxidants status, and protecting the calls from oxidative stress, neutralizing free radicals.


In a study by Professor Rosano involving 107 patients with metabolic syndrome and NAFLD and who were treated for 120 days with polyphenol-rich 38% citrus bergamot extract (BergaMet L). In addition to the expected significant improvements in cholesterol levels, lipid particle characteristics, blood sugar and inflammation, there was a strikingly postive effect on both liver function and structure. Bergamot therapy converted the typical patient from severe steatosis (fatty liver) to the moderate category in 12 weeks. Standard liver function blood test also quickly normalized in the majority of patients.



What is nonalcoholic fatty liver disease (NAFLD)


Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver diseases ranging from the most common, fatty liver (accumulation of fat in the liver, also known as steatosis, to nonalcoholic steatohepatitis to cirrhosis. All of the stages on nonalcoholic fatty liver disease are now believed to be due to insulin resistance, a condition associated with obesity. In fact the BMI correlates with the degree of liver damage, that is, the greater the BMI the greater the liver damage.

The term nonalcoholic is used because due to alcohol can show the same spectrum of liver disease as nonalcoholic fatty liver disease, however, patients with nonalcoholic fatty liver disease do not consume excessive amounts of alcohol.


Alarming statistics about nonalcoholic fatty liver disease.

As expected, nonalcoholic fatty liver disease is observed principally in developed countries. In these societies, a sedentary lifestyle and high calorie, sugar, and fat intake lead to a high prevalence of obesity, insulin resistance, and diabetes. Nonalcoholic fatty liver disease is currently the most common liver disease in the U.5. and worldwide, affecting 1G24% of the world’s population. That means upwards of 29 million Americans and even more alarming than these statistics is the nonalcoholic fatty liver disease that is occurring among children in the U.S.

Why is nonalcoholic fatty liver disease important?

 NAFLD is important for several reasons. First, it is a common disease, affecting approximately 30% of the population and is increasing in prevalence. Second, NASH is an important cause of serious liver disease, leading to cirrhosis and the complications of cirrhosis–liver failure, gastrointestinal bleeding, and liver cancer. Third, NAFLD is associated with other very common and serious non-liver diseases, perhaps the most important being cardiovascular disease that leads to heart diseaseand strokes. Fatty liver probably is not the cause of these other diseases, but is a manifestation of an underlying cause that the diseases share. Fatty liver, therefore, is a clue to the presence of these other serious diseases which need to be addressed.

Weight and exercise are among the most promising of treatments for NAFLD. It does not take large amounts of weight loss to result in a decrease in liver fat. A 7% decrease in weight may be enough. Vigorous exercise results in a reduction of liver fat and also may reduce the inflammation of NASH. The long-term effects of weight loss and exercise on the important development of cirrhosis and its complications are unknown. Nevertheless, at the present time, the best theoretical approach to NAFLD is weight loss and vigorous exercise. Unfortunately, only a minority of patients are able to accomplish these.

What is the relationship between nonalcoholic fatty liver disease and cardiovascular disease?

As mentioned previously, cardiovascular disease, especially heart attacks and strokes, is commonly seen in patients with fatty liver. In fact, cardiovascular causes of death occur more frequently than liver-related deaths. Whereas the components of the metabolic syndrome are risk factors for cardiovascular disease, NAFLD has been found to be a risk factor that is independent of the metabolic syndrome, increasing the risk two-fold. Since the means of treating NAFLD are limited, it is important that the manifestations of the metabolic syndrome – obesity, diabetes, high blood pressure, dyslipidemia (abnormalities of fats or lipids in the blood) – should be aggressively treated.

What diseases are associated with nonalcoholic fatty liver disease?

The diseases of the metabolic syndrome that are associated with NAFLD have already been discussed. Other associations exist including fatty pancreas, hypothyroidismpolyps of the colon, elevated blood uric acid, vitamin D deficiencypolycystic ovaries, and obstructive sleep apnea. For example, 50% of patients with NAFLD have obstructive sleep apnea, and more than 90% of patients with obstructive sleep apnea have NAFLD. Associations do not prove causation, and in most cases it is not clear why the associations exist–whether the associations are due to a causal relationship or they reflect an underlying common cause.

In most patients nonalcoholic fatty liver disease causes no symptoms. Nonalcoholic fatty liver disease often is discovered when routine blood tests show slightly elevated levels of liver enzymes (ALT and AST) in the blood. Another way in which nonalcoholic fatty liver disease is discovered is when ultrasound examination of the abdomen is done for other purposes, say for looking for gallstones, and fat is found in the liver. In the late stages of non alcoholic fatty liver disease, the development of cirrhosis can lead to failure of the liver, swelling of the legs (edema), accumulation of fluid in the abdomen (ascites), bleeding from veins in the esophagus (varices), and mental confusion (hepatic encephalopathy). Patients with cirrhosis caused by Nonalcoholic fatty liver disease also may be at risk of developing liver cancer (hepatocellular carcinoma, HCC).

Care for Your Liver

Here are the proven ways to avoid wrecking your liver:

Don’t drink a lot of alcohol. Alcohol can damage liver cells, leading to the swelling or scarring that becomes cirrhosis, which can be deadly.

According to the federal government’s Dietary Guidelines for Americans, moderate alcohol use is defined as having up to one drink per day for women and up to two drinks per day for men. Stay at or under this to keep from harming your liver.

Eat a healthy diet and get regular exercise. A condition called nonalcoholic fatty liver disease (NAFLD) also can lead to cirrhosis. It comes from being overweight, having diabetes, or having high levels of fat in your blood. NAFLD affects about 25% of people in the U.S. It can be avoided through weight loss if you’re overweight, getting regular exercise, and eating a balanced diet.

Stay away from medicines (or combinations of medicines) that harm the liver. Cholesterol drugs and the painkiller acetaminophen (Tylenol) can be toxic to the liver if too much is taken over time or at once. You may be taking more Tylenol than you realize; it’s found in hundreds of drugs like cold medicines and prescription pain medicines. Certain combinations of drugs can be toxic to the liver; so can taking some medicines while drinking alcohol. Talk to your doctor or pharmacist about what medicines shouldn’t be combined with each other or alcohol. And always follow dosage information.

Be aware of hepatitis and how it is transmitted. Hepatitis is a virus that causes the liver to become inflamed. There are several different types. Hepatitis A is transmitted by water or food that’s been contaminated with bacteria found in feces. It usually gets better on its own. Hepatitis B and C are transmitted through blood and body fluids. If untreated, it can lead to cirrhosis, liver cancer, and liver failure. Hand washing and avoiding places that don’t seem clean can prevent hepatitis A. To prevent hepatitis B and C, don’t share items like toothbrushes, razors, or needles, limit the number of sex partners you have, and always use latex condoms if you have more than one partner.


How to protect your liver

Your liver is a key player in your body’s digestive system. Everything you eat or drink including medicine, passes through your liver. “The liver is a vital organ and not something you can live without,” says Rohit Satoskar, MD, of the MedStar Georgetown Transplant Institute. ” It’s an organ you can easily trash if you don’t take care of it, and once you trash it, it’s gone.”

There’s nothing tricky about keeping your liver in good shape. It’s all about a healthy lifestyle, says Ray Chung, MD of the Liver Center at Massachusetts General Hospital.

“Taking care of your liver is far more about avoiding what’s bad than it is about eating, or drinking things that are particularly nourishing to the liver,” he says.


Body Fat: The silent killer.

obesity is a major health problem worldwide. In the united States, roughly 300,000 deaths per year are related to obesity. Obesity also increases the risk of developing several chronic diseases such as type 11 diabetes, insulin resistance and a form of liver disease called nonalcoholic fatty Liver disease (NAFLD).



 ^ These statements have not been evaluated by the FDA.  This product is not intended to diagnose, treat, cure or prevent any disease. 


David Pryor Australia
I began taking BergaMet Mega just after my colleague Dr. Ross Walker began advertising it on our Healthy Living show on Radio 2UE. It wasn’t long before I began to see results, after cutting down on meal portions and taking BergaMet ahead of main meals of the day, two per day as...
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^ These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.